Equis ISSN 2398-2977

Skin: multisystemic eosinophilic eiptheliotropic disease

Synonym(s): MEED

Introduction

  • Cause: unknown.
  • Signs: exudative dermatitis over face, limbs and ventral abdomen; dullness and inappetence; weight loss, focal alopecia, sometimes with pruritus; watery diarrhea in some cases.
  • Diagnosis: biopsy of affected organs, showing infiltration of eosinophils.
  • Treatment: immunosuppressive doses of corticosteroids.
  • Prognosis: poor.

Pathogenesis

Etiology

  • Not known, but possible exaggerated Type II helper T-lymphocyte response or hypersensitivity response to nematodes have been proposed.

Specific

  • Reported in a small number of cases with concurrent lymphoma    .

Pathophysiology

  • Multisystemic eosinophilic and lymphocytic-plasmacytic infiltrates, leading to the formation of eosinophilic granulomas   Eosinophilic granuloma  in affected organs.

Timecourse

  • Clinical signs often present for long duration before veterinary attention sought.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Horan E M et al (2013) Pulmonary and hepatic eosinophlic granulomas and epistaxis in a horse suggestive of multi-systemic eosinophilic epitheliotropic disease. Equine Vet Educ 25 (12), 607-613 VetMedResource
  • Pucheu-Haston C M & Del Piero F (2013) Equine multi-systemic eosinophilic epitheliotropic disease. Equine Vet Educ 25 (12), 614-617 VetMedResource.
  • Singh K et al (2006) Severe pulmonary disease due to Multisystemic eosinophilic epitheliotrophic disease in a horse. Vet Pathol 43, 189-192 PubMed
  • McCue M E, Davis E G, Rush B R et al (2003) Dexamethasone for treatment of Multisystemic eosinophilic epitheliotrophic disease in a horse. JAVMA 223 (9), 1320-1323 PubMed.
  • Schumacher J, Edwards J F & Cohen N D (2000) Chronic idiopathic inflammatory bowel diseases of the horse. J Vet Intern Med 14, 258-265 PubMed.
  • La Perle K M D, Piercy R J, Long J F & Blomme E A G (1998) Multisystemic, eosinophilic, epitheliotrophic disease with intestinal lymphosarcoma in a horse. Vet Pathol 35, 144-146 PubMed.
  • Hillyer M H & Mair T S (1992) Multisystemic eosinophilic epitheliotrophic disease in a horse: attempted treatment with hydroxyurea and dexamethasone. Vet Rec 130, 392-395 PubMed.
  • Sanford S E (1989) Multisystemic eosinophilic epitheliotrophic disease in a horse. Can Vet J 30, 253-254 PubMed.
  • Nimmo Wilkie J S, Yager J A et al (1985) Chronic eosinophilic dermatitis: a manifestation of a multisystemic, eosinophilic, epitheliotropic disease in five horses. Vet Pathol 22 (4), 297-305 PubMed.


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