Equis ISSN 2398-2977

Neurology: cerebellar abiotrophy

Synonym(s): Cerebellar cortical abiotrophy

Contributor(s): Rachael Conwell, Carla Sommardahl

Introduction

  • Cause: autosomal recessive trait in arabian horses and Arabian bloodlines.
  • Signs: ataxia, wide-based stance and intention tremor in foals, usually apparent within the first 6 months of life.
  • Diagnosis: definitive diagnosis based on histopathology of the cerebellum, but high index of suspicion in young arabian foals with characteristic signs of cerebellar dysfunction. Indirect genetic testing available in the US.
  • Treatment: none available.
  • Prognosis: poor for use as riding horses; breeding not advisable due to genetic inheritance.

Pathogenesis

Etiology

  • Autosomal recessive trait, for which the affected gene has not yet been identified.

Specific

  • Breed: predominantly Arabian bloodlines   Arab  .
  • Progeny of dam and sire that are both presumed carriers.

Pathophysiology

  • Defect resulting in progressive, premature degeneration of Purkinje cells in the cerebellum.

Timecourse

  • Affected animals often normal at birth and gradually develop clinical signs within the first 6 months of age.
  • Generally present between 4 weeks and 6 months of age.

Epidemiology

  • Only seen in specific pedigrees.
  • Carrier frequency in Arabs of 19.7%.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Foley A, Grady J, Almes K, Patton K & Davis E (2011)Cerebellar abiotrophy in a 6 year old Arabian mare.Equine Vet Educ23(3), 130-134 VetMedResource.
  • Johnson A L (2011)Equine cerebellar abiotrophy: searching the genome for an explanation.Equine Vet Educ23(3), 135-137 Wiley Online Library.
  • Blanco Aet al(2006)Purkinje cell apoptosis in Arabian horses with cerebellar abiotrophy.J Vet Med53, 286-287 PubMed.

Other sources of information

  • Mackay R (2008)Neurodegenerative Disorders.In:Equine Neurology. Eds: Furr M & Reed S. Blackwell Publishing, Oxford. pp 235-255.


ADDED