Equis ISSN 2398-2977

Liver: hepatotoxicosis

Synonym(s): Ragwort poisoning, Pyrrolizidine alkaloid toxicity, Chronic megalocytic hepatopathy

Contributor(s): Fairfield T Bain, Michelle Barton, Susan Dawson, Imogen Johns, Clare Knottenbelt, Prof Derek Knottenbelt, Timothy Mair

Introduction

  • Acute or chronic liver failure caused by ingestion of plants of the genusSenecio  Toxicity: pyrrolizidine alkaloid  , EchiumCrotalariaCynoglossumAmsinckia and Heliotropium.
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Pathogenesis

Etiology

  • Ingestion of hepatotoxic pyrrolizidine alkaloids   Toxicity: pyrrolizidine alkaloid  from plants of genusSenecio,Echium,Crotalaria,Cynoglossum,AmsinckiaandHeliotropium.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Moore R E, Knottenbelt D, Matthews J B et al (2008) Biomarkers for ragwort poisoning in horses: identification of protein targets. BMC Vet Res 4, 30 PubMed.
  • Pearson E G (1999) Liver disease in the mature horse. Equine Vet Educ 11, 87-96 VetMedResource.

Organisation(s)

UK

  • For further information and advice on Ragwort contact Rachel Molloy at The British Horse Society on +44 (0)1926 707807 or  r.molloy@bhs.org.uk .


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