Equis ISSN 2398-2977

Liver: hepatitis - chronic active

Contributor(s): Joe Bertone, Susan Dawson, Debbie Deem Morris, Clare Knottenbelt, Prof Derek Knottenbelt, Timothy Mair

Introduction

  • Not a specific dsiease - descriptive term for a group of conditions that involve active, ongoing inflammation of the liver.
  • Cause: chronic liver damage.
  • Signs: appear when 70-75% of liver tissue is non-functional; anorexia, weight loss, abdominal pain, photosensitization, hepatoencephalopathy.
  • Diagnosis: history, signs, biochemistry, cyopathology.
  • Treatment: diet change; supportive care, including antibiotics; steroids may help.
  • Prognosis: very guarded.

Pathogenesis

Etiology

  • Unknown - possibilities include ascending infections from the GIT, toxins, and possibly an immune-mediated process.

Predisposing factors

General

Timecourse

  • Insidious onset of clinical signs.
  • Signs may be intermittent.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Peek S F, McSloy A, Poulsen K P, Friedrichs K R & Chilton J A (2007)Presumptive colchicine​ toxicity in a 17-year-old Arab gelding being treated for chronic active hepatitis.Equine Vet Educ19(8), 431-434 VetMedResource.
  • Peek S F & Divers T J (2000)Medical treatment of cholangiohepatitis and cholelithiasis in mature horses - 9 cases (1991-1998).Equine Vet J32, 301-306 PubMed.
  • Moore J N, Traver D S & Coffman J R (1976)Large bowel obstruction and chronic active hepatitis in a horse.Vet Med Small Anim Clin71(10), 1457-1463 PubMed.


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