Equis ISSN 2398-2977

Keratitis: eosinophilic

Contributor(s): David Donaldson, Paul Gerding, Graham Munroe

Introduction

  • An infrequently occurring disorder in the horse where corneal ulceration is covered by raised and white necrotic plaques.
  • Cause: unknown.
  • Signs: blepharospasm, chemosis, hyperemia, tearing.
  • Diagnosis: clinical signs, cytological examination.
  • Treatment: NSAIDs, keratectomy.
  • Prognosis: good.

Pathogenesis

Etiology

  • Specific cause is unknown.

Predisposing factors

General
  • Allergic or inflammatory manifestation attributable to long-term use of ivermectin   Ivermectin  against such parasitic diseases asOnchocerca  Onchocerca spp  andHabronema  Habronema spp   may be possible causes

Pathophysiology

  • Circulating eosinophils, triggered by release of chemoattractant agents from degranulating mast cells in other tissues, accumulate in corneal stroma.

Timecourse

  • Variable.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Kafarnik C (2010) Equine eosinophilic keratitis. UK Vet 15 (7), 4-6 VetMedResource.
  • Yamagata M, Wilkie D A & Gilger B C (1996) Eosinophilic keratoconjunctivitis in seven horses. JAVMA 209 (7), 12831286 PubMed.
  • Ramsey D T, Whiteley H E, Gerding P A et al (1994) Eosinophilic keratoconjunctivitis in a horse. JAVMA 205, 1308-1311 PubMed.

Other sources of information

  • Barnett K C, Crispin S M, Lavach J D & Matthews A G (2004) Equine Ophthalmology - An Atlas and Text. 2nd edn. W B Saunders.
  • Brooks D E (1999) Equine Ophthalmology. In: Veterinary Ophthalmology. Ed: Gelatt K N. 3rd edn. Lippincott, USA. pp 1053-1116.


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