Equis ISSN 2398-2977

Blood: hyperfibrinogenemia

Synonym(s): Fibrinogenemia

Contributor(s): Prof Gary P Carlson, Prof Derek Knottenbelt, Ruth Morgan

Introduction

  • Excess fibrinogen in the blood   Plasma: fibrinogen  .
  • Major function in final stage of clotting cascade - transformed to fibrin under influence of thrombin.
  • Also produced in response to acute inflammatory process: part of acute phase proteins   Blood: biochemistry - total protein  ; falls into B2 globulin fraction of plasma electrophoresis.
  • Fibrinogen is manufactured in the liver.
  • Cause: natural protein responsible for clotting cascade termination. Elevated in inflammatory disease.
  • Signs: signs of inflammatory or infectious disease, fibrinogen elevations detectable.
  • Diagnosis: plasma measurement - total protein, heat precipitation methods.
  • Treatment: of underlying disease.
  • Prognosis: often poor.

Pathogenesis

Etiology

  • Natural  protein responsible for clotting cascade termination.
  • Released as an acute phase protein.
  • Increased in acute or chronic inflammatory processes.
  • Values >3 g/l consistent with an inflammatory response.
  • Values >7 consistent with profound (chronic) inflammation.
  • Values >10 often carry poor prognosis.

Specific

Timecourse

  • Rapid rises due to inflammation within 24 days.
  • Decline serves as an indication of resolution of inflammatory process.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ferrucci F, Zucca E et al (2008) Bacterial pneumonia and pleuropneumonia in sport horses: 17 cases (2001-2003). Equine Vet Educ 20 (10), 526-531 VetMedResource.
  • Borges A S, Divers T J et al (2007) Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses. J Vet Intern Med 21 (3), 489-494 PubMed.
  • Jacobsen S & Andersen P H (2007) The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses. Equine Vet Educ 19 (1), 38-46 VetMedResource.


ADDED