Canis ISSN: 2398-2942

Synovial fluid: protein

Synonym(s): Joint fluid: protein

Contributor(s): Jane Miller

Overview

  • Protein content varies with changes in vascular permeability and tissue injury or chemotaxis.
  • Synovial fluid protein is elevated in inflammatory joint disease.
  • Used in conjunction with other laboratory tests on synovial fluid to diagnose the effusion type.

Sampling

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Tests

Methodologies

  • A drop of pleural fluid is placed on refractometer plate.
  • Most refractometers are calibrated to give a reading for total protein in g/dl.
  • Refractometry measures the refractive index (RI) of the pleural fluid.
  • The RI changes proportionally to changes in protein concentration.
  • Precipation and dye binding materials.
  • Urinary protein reagent strips for detection of grossly elevated total protein.

Availability

  • Widely available at commercial laboratories.
  • Refractomely can be performed in house.

Technique (intrinsic) limitations

  • Relatively few studies have reported baseline values.

Technician (extrinsic) limitations

Result Data

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Further Reading

Publications

Refereed papers


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