ISSN 2398-2942      

Cerebrospinal fluid: protein

icanis
Contributor(s):

Vetstream Ltd


Overview

  • Total protein and protein fractions vary with type of central nervous sytem (CNS) pathology and etiology.
  • Normally low, increased protein in the cerebrospinal fluid (CSF) may be due to altered permeability of the blood-brain barrier (mainly albumin) and/or local immunoglobulin production.

Sampling

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Tests

Methodologies

  • Precipitation and dye-binding methods.
  • Urinary protein reagent strips for detection of grossly elevated total protein.
  • Protein electrophoresis Serum protein electrophoresis → relative proportions, eg albumin versus globulin, helps identify source of protein: via increased permeability of blood-brain barrier or from local source (production by meninges).
  • Refractometry:
    • A drop of fluid is placed on refractometer plate.
    • Most refractometers are calibrated to give a reading for total protein in g/dl.
    • Refractometry measures the refractive index (RI) of the fluid.
    • The RI changes proportionally to changes in protein concentration.
  • Precipation and dye binding methods.
  • Urinary protein reagent strips for detection of grossly elevated total protein.

Availability

  • Widely available at commecial laboratories.
  • Refractrometry can be done in practice.

Result Data

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code