Canis ISSN: 2398-2942

Blood biochemistry: total bilirubin

Synonym(s): Direct and indirect bilirubinconjugated and unconjugated bilirubin

Contributor(s): Kathleen P Freeman

Overview

  • Peripheral breakdown of red blood cells and myoglobin → unconjugated (indirect) bilirubin → bound to albumin → transported to liver → conjugated with glucuronic acid → excreted in bile.
  • Jaundice, with an increase in total bilirubin, may be primarily due to an increase in direct, or indirect bilirubin or both.
  • In small animals almost all disease causing hyperbilirubinemia → conjugated and unconjugated bilirubinemia.

Sampling

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Tests

Methodologies

  • Van den Bergh method.
  • Measure [total bilirubin] minus [direct bilirubin] = [indirect bilirubin].

Availability

  • Widely available at commercial laboratories.

Technique (intrinsic) limitations

  • Interpret results in conjunction with other laboratory results.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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