Canis ISSN: 2398-2942

Blood biochemistry: creatine phosphokinase

Synonym(s): CPK, CK, Creatinine Kinase

Contributor(s): Kathleen P Freeman

Overview

  • Occurs as 3 isoenzymes in skeletal muscle, cardiac muscle and central nervous system (CNS):
    • CK1 (BB) in brain, peripheral nerve, cerebrospinal fluid and viscera. Not found in serum.
    • CK2 (MB) in cardiac muscle; very small amounts in skeletal muscle.
    • CK3 (MM) in skeletal and cardiac muscle.
  • Most sensitive indicator of muscle damage.
  • Levels peak 6-12 hours post-injury, returning to normal in 2-3 days after cessation of injury. Persistent elevation indicates continuing or active disease.

Sampling

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Tests

Methodologies

  • Methods (and reference interval) vary between laboratories.
  • Enzymatic/spectrophotometric measurement.

Availability

  • Widely available at commercial laboratories.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Aktas M, Auguste D, Concordet D et al (1994) Creatinine kinase in dog plasma - preanalytical factors of variation, reference values and diagnostic significance. Res Vet Sci 56, 30.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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