Canis ISSN: 2398-2942

Pyridostigmine

Synonym(s): Mestinon

Contributor(s): Kyle Braund, Vetstream Ltd

Introduction

Name

  • Pyridostigmine bromide.

Class of drug

  • Anticholinesterase (long acting).

Uses

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Indications

  • Myaesthenia gravis Myasthenia gravis (acquired and congenital forms).
  • Glucocorticoids Prednisolone or other immunosuppressants, eg azathioprine Azathioprine may provide effective adjunctive therapy. However, the use of glucocorticoids is controversial as they may decrease the effectiveness of pyridostigmine.

Administration

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Precautions

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Interactions

with other drugs

Aminoglycosides, clindamycin, lincomycin, polymyxins and propranolol

  • May antagonise the effect of pyridostigmine.

Suxamethonium

Non-depolarizing muscle relaxants

  • Pyridostigmine may antagonize the effect.
  • Corticosteroids may decrease the anticholinesterase activity of pyridostigmine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Dewey C W et al (1999) Azathioprine therapy for acquired myasthenia gravis in five dogs. JAAHA 35(5), 396-402.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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