Canis ISSN: 2398-2942

Prednisolone

Contributor(s): Stephen Barr

Introduction

Name

  • Prednisolone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (11-beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione.

Molecular formula

  • C21H28O5.

Physical properties

  • Tablets.

Storage requirements

  • <25°C.
  • In a dry environment.
  • In its original tight container.
  • Protect from light.

Uses

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Indications

  • Anti-inflammatory.
  • Immunosuppression.
  • Anti-fibrotic.
  • Aid in management of hypoadrenocorticism Hypoadrenocorticism.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Acetazolamide, amphotericin B or potassium-depleting diuretics, eg furosemide, thiazides
  • Increased risk of hypokalemia.
Insulin
  • May antagonize the effects of insulin Insulin.
Phenytoin or phenobarbitone

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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