ISSN 2398-2942      

Phenylpropanolamine / diphenylpyraline

icanis

Synonym(s): PPA, Propalin, Urilin


Introduction

Name

  • Phenylpropanolamine.

Class of drug

  • Sympathomimetic amine.

Description

Chemical name

  • 4-(diphenylmethoxy)-1-methylpiperidine.

Molecular formula

  • C19H23NO.

Physical properties

  • Clear liquid.

Storage requirements

  • <25°C.
  • In a dry environment.
  • Do not store in fridge.

Uses

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Indications

  • Management of urinary incontinence Urinary incontinence by increasing urethral outflow resistance.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Monoamine oxidase (MAO) inhibitors - do not give PPA within 2 weeks of MAO inhibitors.
  • Avoid with other sympathomimetics, eg ephedrine, epinephrine Epinephrine.
  • Avoid use with concurrent NSAIDs as may increase risk of hypertension.
  • Can cause cardiac arrhythmias if given with halogenated hydrocarbon anesthetic agents.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Scott L, Leddy M, Bernay F and Davot J L (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. JSAP 43, 493-496 PubMed.

Other sources of information

  • Plumb D C (2002) Veterinary Drug Handbook. 4th edn. Iowa State University Press, USA.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.
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