Canis ISSN: 2398-2942

Pentoxifylline

Contributor(s): Vetstream Ltd

Introduction

Name

  • Pentoxifylline.

Class of drug

  • Hemorrheologic.
  • Immunomodulatory agent.
  • Methylxanthine derivative.

Description

Chemical name

  • Hemorrheologic.
  • Immunomodulatory agent.
  • Methylxanthine derivative.

Molecular formula

  • C13H18N4O3.

Molecular weight

  • 278.31

Physical properties

  • White, odorless, bitter-tasting, crystalline powder.
  • At room temperature, 77 mg are soluble in 1 mL of water and 63 mg are soluble in 1 mL of alcohol.

Storage requirements

  • Store at room temperature, in well-closed containers and protected from light.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

Antihypertensive drugs
  • Pentoxifylline may potentiate hypotensive effects.
Platelet-aggregation inhibitors, eg aspirin, and warfarin
  • Increased risk for bleeding.
Theophylline
  • Serum levels may be increased when used with pentoxifylline.
Ciprofloxacin and Cimetidine
  • May increase pentoxifylline levels.

Side effects

  • Nausea, vomiting and diarrhea.
  • Anecdotally thrombocytopenia Thrombocytopenia, bone marrow suppression and flushing have been reported in dogs.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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