Canis ISSN: 2398-2942

Mitratapide

Synonym(s): Yarvitan

Contributor(s): Linda Horspool

Introduction

Name

  • Mitratapide.

Class of drug

  • Microsomal triglyceride transfer protein inhibitor.

Description

Chemical name

  • 4-[4-[4-[4-[[(2S,4R)-2-(4-Chlorophenyl)-2-[[(4-methyl-4H-1,2,4-triazol-3-yl)thio]methyl]-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(1R)-1-methylpropyl]-3H-1,2,4-triazol-3-one

Molecular formula

  • C36H41ClN8O4S

Molecular weight

  • 717.28

Physical properties

  • Colorless to slightly yellow solution.

Storage requirements

  • Do not refrigerate.
  • After each dose, the pipette should be washed and dried and the bottle cap screwed back on tightly.
  • Shelf-life after first opening the immediate packaging: 3 months.

Uses

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Indications

  • As an aid in the management of overweight and obesity Obesity in adult dogs. To be used as part of an overall weight management program, which also includes appropriate dietary and lifestyle changes (eg increased exercise).

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • No drug interactions were observed when administered concomitantly with NSAIDs (carprofen Carprofen , meloxicam Meloxicam ) or ACE inhibitors (enalapril Enalapril , benazepril Benazepril ).
  • Interactions with other drug types were not specifically investigated.
  • Monitor drug interactions closely.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Gossellin J, Wren J A & Sunderland S J (2007)Canine obesity an overview.J Vet Pharmacol Ther30Suppl 1, 1-10 (Review)PubMed.
  • Vandaele E (2007)Treatment of obesity in the dog: Mitratapide blocks triglyceride resorption.Point Veterinaire38(274), 16-17.

Other sources of information


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