ISSN 2398-2942      

Mirtazapine

icanis

Synonym(s): Remeron®, Mirataz®, Zispin


Introduction

Name

  • Mirtazapine.

Class of drug

  • Tetracyclic antidepressant.

Description

Chemical name

  • 1,2,3,4,10,14b-hexahydro-2-methylpyrazino [2,1-a] pyrido [2,3-c] benzazepine

Molecular formula

  • C17H19N3

Molecular weight

  • 265.36

Physical properties

  • White to creamy white crystalline powder.
  • Available as 15, 30 and 45 mg tablets (oral distintegrating) and 7.5, 15 and 30 mg tablets (scored film-coated).

Storage requirements

  • The coated tablets and the orally disintegrating tablets should be stored at 25°C (77ºF) with excursions permitted to 15-30°C (59-86°F). 
  • Protect from light and moisture.
  • The stability of the orally disintegrating tablets once removed from the tablet blister is unknown and immediate use is recommended.

Uses

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Indications

  • Appetite stimulant and anti-nausea drug.

Administration

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Pharmacokinetics

Precautions

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Interactions

With other drugs

  • Clonidine Clonidine: mirtazapine may cause increases in blood pressure.
  • Cyproheptadine Cyproheptadine: may negate the effects of mirtazapine.
  • Diazepam Diazepam (and other benzodiazepines): minimal effects on mirtazapine blood levels, but may cause additive impairment of motor skills.
  • Fluvoxamine: may cause increased serum concentrations of mirtazapine.
  • Linezolid: increased risk for serotonin syndrome.
  • Selegiline Selegiline, Amitraz Amitraz: increased risk for serotonin syndrome; MAO inhibitors considered contraindicated with mirtazapine.
  •  Tramadol Tramadol: increased risk for serotonin syndrome.

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Giorgi M, Yun H (2012) Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study. Vet J 192 (2), 239-241 PubMed
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