ISSN 2398-2942      

Methylprednisolone

icanis
Contributor(s):

Vetstream Ltd


Introduction

Name

  • Methylprednisolone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (6-alpha,11-beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H30O5.

Physical properties

  • Sterile, aqueous suspension.
  • Sterile, freeze-dried powder.

Storage requirements

  • <25°C.
  • Do not store in freezer.

Uses

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Indications

  • Anti-inflammatory suitable for alternate day use.
  • Treatment for shock Shock.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (frusemide, thiazides)

  • Hypokalemia may develop.

Insulin

  • Insulin Insulin requirements are likely to increase.

Phenobarbitone or phenytoin

  • The metabolism of corticosteroids may be enhanced Phenobarbital Phenytoin.
  • Increased risk of gastrointestinal ulceration if used concurrently with NSAIDs.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.
  • Will increase steroid induced alkaline phoshatase in dogs.
  • Some cross reaction with cortisol assay. May interfere with interpretation of other tests eg ACTH stimulation test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 
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