Canis ISSN: 2398-2942

Methylprednisolone

Introduction

Name

  • Methylprednisolone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (6-alpha,11-beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H30O5.

Physical properties

  • Sterile, aqueous suspension.
  • Sterile, freeze-dried powder.

Storage requirements

  • <25°C.
  • Do not store in freezer.

Uses

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Indications

  • Anti-inflammatory suitable for alternate day use.
  • Treatment for shock Shock.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Amphotericin B or potassium-depleting diuretics (frusemide, thiazides)
  • Hypokalemia may develop.
Insulin
  • Insulin Insulin requirements are likely to increase.
Phenobarbitone or phenytoin
  • The metabolism of corticosteroids may be enhanced Phenobarbital Phenytoin.
  • Increased risk of gastrointestinal ulceration if used concurrently with NSAIDs.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.
  • Will increase steroid induced alkaline phoshatase in dogs.
  • Some cross reaction with cortisol assay. May interfere with interpretation of other tests eg ACTH stimulation test.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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