Canis ISSN: 2398-2942

Meloxicam

Contributor(s): Cheryl Blaze, Kyle Braund, Vetstream Ltd

Introduction

Name

  • Meloxicam.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.

Molecular formula

  • C14H13N3O4S2.

Physical properties

  • Pale yellow suspension.
  • Characteristic odor of honey.

Storage requirements

  • <25°C.

Uses

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Indications

  • Alleviates mild to moderate musculo-skeletal pain and inflammation.
    Analgesic action is enhanced if administered pre-emptively.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Fluoroquinolones

  • Increase risk of convulsions (in man).

Anti-hypertensives, eg beta-blockers

  • Hypotensive effects may be antagonized.

Diuretics, aminoglycosides

  • May increase risk of nephrotoxicity.

with diagnostic tests

  • May cause false low values for T3 and T4.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Jones C J, Streppa H K, Harmon B G & Budsberg S C (2002) In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. Am J Vet Res 63(11), 1527-1531 PubMed.
  • Doig P A, Purbrick K A, Hare J E & McKeown D B (2000) Clinical efficacy and tolerance of meloxicam in dogs with chronic osteoarthritis. Can Vet J 41,296-300 PubMed.
  • Rainsford K D et al (1999) Effects of the NSAIDs meloxicam and indomethacine on cartilage proteoglycan synthesis and joint reponses to calcium pyrophosphate crystals in dogs. Vet Res Commun 23(2), 101-113 PubMed.

Other sources of information


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