Canis ISSN: 2398-2942

Ketamine

Contributor(s): John Dodam, Sheilah Robertson, Jo Murrell

Introduction

Name

  • Ketamine.

Class of drug

  • Cyclohexanone derivative.
  • N-methyl-D-aspartate receptor antagonist.

Description

Chemical name

  • (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Molecular formula

  • C13H16ClNO

Physical properties

  • Clear solution.

Storage requirements

Uses

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Indications

  • A dissociative anesthetic/analgesic used to provide restraint or dissociative anesthesia.
  • Dissociative anesthesia is associated with mild stimulation of cardiac output and blood pressure, modest respiratory depression and preservation of cranial nerve reflexes.
Eyes remain open during anesthesia. Bland ophthalmic lubricant should be usedKetamine alone does not provide sufficient analgesia for ovariohysterectomy Ovariohysterectomy.
  • Provision of intra-operative and post-operative analgesia when administered intravenously by continuous rate infusion (CRI). May be particularly useful to provide analgesia in animals with upregulated pain states.

Administration

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Sarrau S, Jourdan J, Dupuis-Soyris F et al (2007) Effects of postoperative ketamine infusion on pain control and feeding behaviour in bitches undergoing mastectomy. J Small Anim Pract 48 (12), 670-676 PubMed.
  • Wagner A E, Walton J A, Hellyer P W et al (2002) Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. J Am Vet Med Assoc 221 (1), 72-75 PubMed.

Other sources of information

  • Ramsey I (2017) Small Animal Formulary. 9th edn. Cheltenham: BSAVA.

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