Canis ISSN: 2398-2942

Hydromorphone

Contributor(s): John Dodam, Vetstream Ltd

Introduction

Name

  • Hydromorphone.

Class of drug

Description

Chemical name

  • Hydromorphone hydrochloride.

Molecular formula

  • 4,5±-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride.

Molecular weight

  • 321.80.

Physical properties

  • White powder that is freely soluble in water.
  • Semi-synthetic phenanthrene alkaloid of opium.

Storage requirements

  • Store at 15-30°C.
  • Protect from light.

Uses

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Indications

  • For the relief of pain.
  • Can be used pre-emptively for elective surgical procedures.
  • Can be used to relieve pain from trauma Trauma: overview.
  • Has also been used to provide longer-term pain relief, for example that caused by osteosarcoma Osteosarcoma.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can cause profound sedation when combined with acepromazine Acepromazine maleate , alpha2-agonists (xylazine Xylazine , medetomidine Medetomidine ) and benzodiazepines.
  • Hydromorphone may reduce the induction dose of injectable anesthetic agents and lower the dose of inhalant agents required for maintenance of anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pettifer G & Dyson D (2000) Hydromorphone: a cost-effective alternative to the use of oxymorphone.​ Can Vet J 41 (2), 135-137 PubMed.

Other sources of information

  • Pascoe P J (2000) Opioid Analgesics. In: Management of Pain. Vet Clin North Am Small An Pract 30 (4), 757-772.

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