ISSN 2398-2942      

Hydrochlorothiazide

icanis
Contributor(s):

Vetstream Ltd


Introduction

Name

  • Hydrochlorothiazide.

Class of drug

  • Thiazide diuretic.

Description

Chemical name

  • 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.

Molecular formula

  • C7H8ClN3O4S2.

Physical properties

  • Tablets.
  • Oral solution.

Uses

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Indications

  • Ascites.
  • Pleural effusion Pleural: effusion.
  • Edema.
  • Hypertension Hypertension.
  • When using hydrochlorthiazide to treat hypertension, if potassium loss is/may be a clinical problem, it should be used in combination with a potassium sparing diuretic, eg amiloride.
  • To inhibit lactation in pseudopregnancy.

Administration

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Precautions

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Interactions

with other drugs

Corticosteroids

  • Increased possibility of hypokalemia developing.

Digoxin

  • Thiazide-induced hypokalemia may increase the risk of digoxin toxicity Digoxin. Thus, potassium therapy may be necessary during prolonged administration.

Sulfonamides

  • May potentiate thiazide activity.

Quinidine

  • Half-life may be prolonged by thiazides (alkalinizes urine) Quinidine.

Diazoxide

  • Increased chance of hyperglycemia, hyperuricemia and hypotension Diazoxide.

Vitamin D or calcium salts

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (1999) 9th edn. 
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