Canis ISSN: 2398-2942

Furosemide

Synonym(s): Frusemide

Introduction

Name

  • Frusemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid.
  • 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Molecular formula

  • C12H11ClN2O5S.

Physical properties

  • White tablets.
  • Solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Congestive heart failure

  • There is evidence, although yet to be proven, that frusemide may acutely increase venous capacitance. This would be of benefit in the management of congestive cardiac failure.

    The use of chronic diuretic monotherapy in the management of cardiac failure should be avoided, as patients receiving diuretics alone may deteriorate more rapidly than those receiving ACE inhibitors or digoxin concurrently.

Administration

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Precautions

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Interactions

with other drugs

ACE inhibitors and digoxin
  • Combination of frusemide, ACE inhibitor and digoxin with a sodium restricted diet may be associated with mild hyperkalemia.
TheophyllineAminoglycosides
  • Nephrotoxicity associated with the aminoglycosides may be potentiated.
Digoxin
  • Frusemide may induce hypokalemia, thereby increasing the risk of digoxin toxicity Digoxin.
Aspirin
  • The excretion of both drugs may be reduced as they both compete for renal excretory sites; dose reduction may be required Acetyl salicylic acid.
Tubocurarine
  • May inhibit the muscle relaxation qualities.
Suxamethonium

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant B (1999) 3rd edn. Cheltenham: BSAVA.

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