Canis ISSN: 2398-2942

Fluoxetine hydrochloride

Synonym(s): For veterinary use - Reconcile®; For human use - Prozac®, Sarafem®, Ladose®, Fontex®

Contributor(s): Linda Horspool

Introduction

Name

  • IUPAC.

Class of drug

  • Antidepressant.
  • Selective serotonin re-uptake inhibitor (SSRI) class.

Description

Chemical name

  • (RS)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

Molecular formula

  • C17H18F3NO-HCl

Molecular weight

  • 345.79

Physical properties

  • White to off-white crystalline solid.
  • Water Solubility: 14 mg/mL.
  • Octanol-water Partition Coefficient (log P, pH 7): 4.1.
  • Product as packaged for sale:
  • 8, 16, 32 and 64 mg tablets, in bottles containing 30 tablets - approved for veterinary use in dogs in the US.
  • 10 mg tablets - not approved for veterinary use.
  • 10, 20 and 40 mg tablets - not approved for veterinary use.
  • 4 mg/mL syrup - not approved for veterinary use.

Storage requirements

  • Veterinary product as packaged for sale:
    • Store at 20-25ºC (68-77ºF).
    • Excursions permitted between 15-30ºC (59-86ºF).
    • Do not remove desiccant canister from the bottle.

Uses

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Indications

  • Treatment of canine separation anxiety Separation anxiety , in conjunction with a behavior modification plane:
    • Approved for use the US.
  • Treatment of aberrant compulsive behaviors Stereotype behavior , eg lick granulomas, self-mutilation, psychogenic pruritus/alopecia.
  • Dominance aggression in dogs Intraspecific intolerance.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Mixed function oxidase (cytochrome P450) inhibitor - administer with care with other agents undergoing hepatic metabolism. A washout period of 6 weeks may be required before commencing other treatment due to the long half-lives of fluoxetine and norfluoxetine.
  • Do not give in combination with a monoamine oxidase inhibitor (MAOI) for example, selegiline hydrochloride Selegiline hydrochloride (L-deprenyl) or amitraz Amitraz , or within a minimum of 14 days of discontinuing therapy with an MAOI.
  • Do not give concomitantly with drugs that lower the seizure threshold (eg phenothiazines such as acepromazine Acepromazine maleate or chlorpromazine).
  • Use with care concomitantly with aspirin Acetyl salicylic acid or other anticoagulants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromVetMedResourceandPubMed.
  • Fitzgerald KT, Bronstein AC (2013)Selective serotonin reuptake inhibitor exposure.Top Companion Anim Med28:13-17PubMed.
  • Thomas DE, Lee JA, Hovda LR (2012)Retrospective evaluation of toxicosis from selective serotonin reuptake inhibitor antidepressants: 313 dogs (2005-2010).J Vet Emerg Crit Care22, 674-681PubMed.
  • Kukanich B, Kukanich KS, Rodriguez JR (2011)The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs.Vet Anaesth Analg38(3), 224-230PubMed.
  • Rosado B, García-Belenguer S, León M, Chacón G, Villegas A, Palacio J (2011)Effect of fluoxetine on blood concentrations of serotonin, cortisol and dehydroepiandrosterone in canine aggression.J Vet Pharmacol Ther34(5), 430-436PubMed.
  • Yalcin E (2010)Comparison of clomipramine and fluoxetine treatment of dogs with tail chasing.Tierarztl Prax Ausg K Kleintiere Heimtiere38, 295-299PubMed.
  • Irimajiri M, Luescher AU, Douglass G, Robertson-Plouch C, Zimmermann A, Hozak R (2009)Randomized, controlled clinical trial of the efficacy of fluoxetine for treatment of compulsive disorders in dogs.J Am Vet Med Assoc235, 705-709PubMed.
  • Simpson BS, Landsberg GM, Reisner IR, Ciribassi JJ, Horwitz D, Houpt KA, Kroll TL, Luescher A, Moffat KS, Douglass G, Robertson-Plouch C, Veenhuizen MF, Zimmerman A, Clark TP (2007)Effects of reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety.Vet Ther8, 18-31PubMed.
  • Jochle W (1998)Abnormal behaviors and adaptation problems in dogs and cats and their pharmacological control.Tierarztl Prax Ausg K Klientiere Heimtiere26(6), 410-421.
  • Wynchbank D & Berk M (1998)Fluoxetine treatment of acral lick dermatitis in dogs - a placebo control randomised double blind trial.Depress Anxiety8(1), 21-23.
  • Wynchank D & Berk M (1998b)Behavioral changes in dogs with acral lick dermatitis during a 2-month extension phase of fluoxetine treatment.Hum Psychopharmacol Clin Exp13, 435-437.
  • Pohland R C & Bernhard N R (1997)Postmortem serum and tissue redistribution of fluoxetine and norfluoxetine in dogs following oral administration of fluoxetine hydrochloride (Prozac).J Forensic Sci42(5), 812-816.
  • Rapaport J L, Ryland D H & Kriete M (1992)Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder.Arch Gen Psychiatry49(7), 517-521.

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