Canis ISSN: 2398-2942

Erythropoietin

Synonym(s): EPO; r-HuEPO

Contributor(s): Kate Murphy

Introduction

Name

  • Erythropoietin
  • r-Human Erythropoietin.

Class of drug

  • Synthetic hormone.
  • Hemopoietic growth factor.

Description

Chemical name

  • Erythropoietin, epoetin alfa, recombinant human erythropoietin (rHuEPO).

Molecular weight

  • Approximately 30,000.

Physical properties

  • Sterile, colorless solution.

Storage requirements

  • Store in refrigerator at 2-8°C, do not freeze. Do not shake. Single use vial because it contains no preservatives.

Uses

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Indications

  • Treatment of anemia due to chronic kidney disease in dogs and cats Kidney: chronic kidney disease (CKD).
  • Used to treat anemic human patients with cancer and cats with FeLV-associated anemia.
  • Also reported in the treatment of myelodysplastic syndromes in dogs (Weiss 2003).
  • Not indicated in conditions where high serum concentrations of the hormone already exist, eg hemolytic anemia, anemia due to blood loss, where anemia is due to iron deficiency or if hypertension is present.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Androgens - may increase sensitivity to EPO.
  • Desmopressin Desmopressin - decreased bleeding times.

with diagnostic tests

  • Will increase hemocrit and reticulocyte count.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Roudebush P, Polzin D J, Adams L G, Towell T L, Forrester S D (2010)An evidence-based review of therapies for canine chronic kidney disease.JSAP51(5), 244-252PubMed.
  • Langston C E, Reine N J, Kitrell D (2003)The use of erythropoietin.Vet Clin North Am Small Anim Pract33(6), 1245-1260PubMed.
  • Weiss D J (2003)New insights into the physiology and treatment of acquired myelodysplastic syndromes and aplastic pancytopenia.Vet Clin North Am Small Anim Pract33(6), 1317-1334PubMed.
  • Cowgill L Det al(1998)Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure.JAVMA212(4), 521-528PubMed.

Other sources of information

  • Plumb D C (2008)Plumb's Veterinary Drug Handbook.pp 349-351, Blackwell Publishing, Ames, Iowa.

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