Canis ISSN: 2398-2942

Cyclophosphamide

Contributor(s): William Brewer Jr

Introduction

Name

  • Cyclophosphamide.

Class of drug

  • Nitrogen mustard group.

Description

Chemical name

  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate.
  • 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate.

Molecular formula

  • C7H15Cl2N2O2P.H2O.

Physical properties

  • Lyophilized powder.
  • Tablets.

Storage requirements

  • Room temperature.
  • Reconstituted powder stable for 24 hours at room temperature and for 6 days under refrigeration.

Uses

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Indications

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Digoxin
  • See also digoxin Digoxin.
  • May decrease absorption of concomitantly administered oral digoxin.
Barbiturates
  • May increase cyclophosphamide toxicity (increases rate of conversion to metabolites Phenobarbital ).
Phenothiazines
  • May decrease cyclophosphamide efficacy by inhibiting activation of P450 enzymes which activate cyclophosphamde.
Chloramphenicol and corticosteroids
  • May decrease cyclophosphamide efficacy by inhibiting activation of P450 enzymes which activate cyclophosphamide.
Doxorubicin

with diagnostic tests

  • Frequent urinalysis is recommended for the early detection of hemorrhagic cystitis.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Fischer D S, Knobf MTet al(2003)The Cancer Chemotherapy Handbook.6th edn. Philadelphia, PA. Mosby. pp 90-92.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Frazier D l & Hahn K A (1995)Commonly Used Drugs.In: Hahn K A & Richardson R C (eds)Cancer Chemotherapy A Veterinary Handbook. Philadelphia, PA. Williams & Wilkins.pp 94-95.

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