Canis ISSN: 2398-2942

Amitryptiline

Contributor(s): Rosanna Marsella, Vetstream Ltd

Introduction

Name

  • Amitryptiline.

Class of drug

  • Tricyclic antidepressant.

Description

Physical properties

  • Soluble in water and alcohol.
  • Bitter taste.

Uses

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Indications

  • Management of pruritus and psychogenic dermatoses where anxiety is a component.
  • Controlling urine marking in cats.
  • Management of feline lower urinary tract disorders.

Administration

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Precautions

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Interactions

with other drugs

Anesthetics and anti-dysrhythmics

  • Increased risk of dysrhythmias.

Anti-epileptics

  • Antagonizes the effects of anti-epileptics.
  • Cimetidine → reduces metabolism of amitriptyline → increased concentration of amitriptyline.

Sedatives

  • Increases sedative effect if used with other sedative drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Scott D W & Miller W H Jr. (1993) Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus. J S Afr Vet Assoc 64 (1), 52-56 PubMed.
  • Miller W H Jr., Scott D W & Wellington J R (1992) Nonsteroidal management of canine pruritus with amitriptyline. Cornell Vet 82 (1), 53-57 PubMed.
  • Friehe H & Fontaine R (1978) Toxicology of amitriptylinoxide. Arzneimittelforschung 28 (10b), 1898-1907 PubMed.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb D Veterinary Drug handbook 3 edn. pp 34-36.

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