Canis ISSN: 2398-2942

Acepromazine maleate

Synonym(s): ACP

Contributor(s): Sheilah Robertson, Vetstream Ltd

Introduction

Name

  • Acepromazine maleate

Class of drug

  • Phenothiazine.

Chemical name

  • 1-[10-[3-(dimethylamino)propyl]-10 H-phenothiazin-2-yl]ethanone.
  • 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone.

Molecular formula

  • C19H22N2OS.C4H4O4.

Physical properties

  • Pale yellow solution or tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

  • Other central nervous system (CNS) depressants (barbiturates [Pentobarbital] , opioids, anesthetics) may cause additive CNS depression.
  • Quinidine may cause additive cardiac depression.
  • Anti-diarrheal mixtures , eg kaolin/pectin , bismuth subsalicylate, and antacids may decrease gastrointestinal (GI) absorption of oral phenothiazine.
  • Propranolol : may increase blood levels of both drugs.
  • Epinephrine : may lead to unopposed beta activity hence vasodilation and tachycardia because phenothiazines block alpha-adrenergic receptors.
  • Phenytoin : metabolism may be decreased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.

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