Canis ISSN: 2398-2942

Inflammatory bowel disease: overview

Synonym(s): IBD

Contributor(s): Julien Bazelle, Ed Hall, Ken Harkin

Introduction

  • Most common cause of chronic vomiting Vomiting and diarrhea Diarrhea: overview.
  • Cause: any idiopathic inflammatory condition of the small or large intestine:
  • Signs: chronic gastroenteritis (diarrhea and vomiting), weight loss.
  • Characterized by infiltration of gastrointestinal tract with inflammatory cells including:
    • Lymphocytes.
    • Plasma cells.
    • Eosinophils.
    • Macrophages.
    • Neutrophils (rarely).
  • Diagnosis: idiopathic nature makes it a diagnosis of exclusion.
  • Treatment: dietary change, immunosuppressive therapy (prednisolone/cyclosporine/chlorambucil).
  • Prognosis: good with appropriate treatment.
    Print off the owner factsheet on Inflammatory bowel disease Inflammatory bowel disease to give to your client.

Pathogenesis

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Signs

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Diagnosis

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Treatment

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Dandrieux J R, Noble P J, Scase T J, Cripps P J & German A J (2013) Comparison of a chlorambucil-prednisolone combination with a azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010). JAVMA 242, 1705-1714 PubMed.
  • Dye T L, Diehl K J, Wheeler S L & Westfall D S (2013) Randomized, contolled trial of budesonide and prednisone for the treatment of idiopathic inflammatory bowel disease in dogs. JVIM 27, 1385-1391 PubMed.
  • Maeda S, Ohno K, Uchida K, Nakashima K, Fukushima K, Tsukamoto A, Nakajima M, Fujino Y & Tsujimoto H (2013) Decreased immunoglobulin A concentrations in feces, duodenum, and peripheral blood mononuclear cells of dogs with inflammatory bowel disease. JVIM 27, 47-55 PubMed.
  • Gow A G, Else R, Evans H, Beery J L, Herrtage M E & Mellanby R J (2011) Hypovitaminosis D in dogs with inflammatory bowel disease and hypoalbuminemia. JSAP 52, 411-418 PubMed.
  • Jergens A E, Crandell J, Morrison J A, Deitz K, Pressel M, Ackermann M, Suchodolski J S, Steiner J M & Evans R (2010) Comparison of oral prednisone and prednisone combined with metronidazole for induction therapy of canine inflammatory bowel disease: a randomized-controlled trial. JVIM 24, 269-277 PubMed.
  • The WSAVA International Gastrointestinal Standardisation Group (2010) Endoscopic, biopsy and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. JVIM 24, 10-26 PubMed.
  • Mandigers P J, Biourge V, van den Ingh T S, Ankringa N & German A J (2010) A randomized, open-label, positively-controlled field trial of a hydrolysed protein diet in dogs with chronic small bowel enteropathy. JVIM 24, 1350-1357 PubMed.
  • Kathrani A, Steiner J M, Suchodolski J, Estwood J, Syme H, Garden O A & Allenspach K (2009) Elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease is associated with a negative outcome. JSAP 50, 126-132 PubMed.
  • Allenspach K, Wieland B, Grone A & Gaschen F (2007) Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. JVIM 21, 700-708 PubMed.
  • Rudorf H, van Schaik G, O'Brien R T, Brown P J, Barr F J & Hall E J (2005) Ultrasonographic evaluation of the thickness of the small intestinal wall in dogs with inflammatory bowel disease. JSAP 46, 322-326.
  • Sturgess K (2005) Diagnosis and management of idiopathic inflammatory bowel disease in dogs and cats. In Practice 27, 293-301.
  • Craven M, Simpson J W, Ridyard A E & Chandler M L (2004) Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). JSAP 45(7), 336-342 PubMed.
  • Jergens A E, Moore F M & Haynes J S (1992) Idiopathic inflammatory bowel disease in dogs and cats; 84 cases (1987-1990). JAVMA 201, 1603-1608.
  • Jergens A E, Moore F M, March P & Miles K G (1990) Gastrointestinal ulceration associated with inflammmatory bowel disease in the dog. JVIM 4, 121.
  • Marks S L (1998) Management of canine inflammatory bowel disease. Comp Cont Ed Pract Vet 20, 317-332.
  • Batt R M & Hall E J (1989) Chronic enteropathies in the dog. JSAP 30, 3-12.


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