Canis ISSN: 2398-2942

Allergen-specific immunotherapy

Synonym(s): ASIT, hyposensitization

Contributor(s): David Godfrey, Charlie Walker

Introduction

  • Allergen-specific immunotherapy is suggested to alter the immune response to allergens and, as such, other than allergen avoidance, it is theoretically the best treatment for atopic dermatitis Skin: atopy as it treats the primary conditions itself.
    • It changes a Th2 response to a Th1 response with altered cytokine expression.
    • It induces activity of T-reg cells which express suppressive cytokines.
    • IgG production increases with may capture antigen that might otherwise cause allergic reactions.

When to recommend ASIT

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Types of immunotherapy

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Side-effects of immunotherapy

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Concurrent use with anti-inflammatory treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • DeBoer D J, Verbrugge M, Morris M (2016) Clinical and immunological responses of dust mite sensitive, atopic dogs to treatment with sublingual immunotherapy (SLIT). Vet Dermatol 27, 82-87 PubMed.
  • Olivry T, DeBoer D J, Favrot C et al (2015) Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res 11, 210-224 PubMed.
  • Willemse A, Van den Brom W E, Rijnberk A (1984) Effect of hyposensitization on atopic dermatitis in dogs. JAVMA 10, 1,277-1,280 PubMed.

Other sources of information

  • Foster A (2019) Using 'allergy tests' in cases of canine dermatitis. In Practice 41, 115-120 (https://inpractice.bmj.com/content/41/3/115).
  • Favrot C (2017) What is new in allergen-specific immunotherapy? In: Proceedings of 29th Annual ESVD-ECVD Congress, Lausanne.
  • Miller W H, Griffin C E & Campbell K L (2013) Hypersensitivity disorders - allergen-specific immunotherapy. In: Muller & Kirk’s Small Animal Dermatology. 7th edn. Elsevier Inc, Missouri,  pp 383.
  • Scott K V, White S D, Rosychuk R A W et al (1993) A retrospective study of hyposensitization in atopic dogs in a flea-scarce environment. In: Ihrke P J, Mason I S, White S D, eds. Advances in Veterinary Dermatology. volume 2. New York: Pergamon Press, 79-87.


ADDED