ISSN 2398-2969      

Zinc deficiency

icanis
Contributor(s):

Rosanna Marsella

Synonym(s): Zn deficiency; Zinc responsive dermatosis


Introduction

  • Rare dietary deficiency.
  • Arctic breeds predisposed.
  • Cause: usually dietary interactions decreasing zinc bio-availability,primary deficiency unlikely if dog fed commercial food.
  • Signs: mostly cutaneous, erythema, crusting, scale of areas adjacent to mucosa.
  • Diagnosis: histopathology.
  • Treatment: balanced diet, zinc supplement.
  • Prognosis: excellent to poor depending on cause.

Pathogenesis

Etiology

  • Absolute lack of zinc.
  • Nutritional antagonism.
  • Individual defect, eg lethal acrodermatitis Skin: acrodermatitis.

Predisposing factors

General
  • High dietary [calcium], [iron] or [copper].
  • Poor quality diet.
  • High dietary [phytate], eg soybean and cereal.
  • Breed: giant breed fed poor quality diet or diet which nutritionally interacts to decrease absorption of zinc may present with similar cutaneous signs.

Pathophysiology

  • Absolute lack: diet lacking zinc - possible but rare.
  • Nutritional antagonism: diet containing high levels of calcium, iron, copper or phytates → binds zinc → prevents intestinal absorption of zinc.
  • Individual defect: Arctic breeds → fed nutritionally balanced diet → unable to absorb enough zinc from diet.
  • English Bull Terrier: adequate dietary zinc → metabolic inability to utilize zinc → lethal acrodermatitis.

Timecourse

  • Signs develop slowly, may be precipitated by stress.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hall J (2005) Diagnostic dermatology. Zinc responsive dermatosis. Can Vet J 46 (6), 555-557 PubMed.
  • Roudebush P & Wedekind K J (2002) Zinc-responsive dermatosis in dogs. Vet Dermatol 13 (1), 63 PubMed.
  • White S D, Bourdeau P, Rosychuk R A et al (2001) Zinc-responsive dermatosis in dogs: 41 cases and literature review. Vet Dermatol 12 (2), 101-109 PubMed.
  • Jackson H (1999) Common cutaneous diseases of the canine foot. In Practice 21 (2), 54-61 VetMedResource.
  • Thoday K L (1989) Diet-related zinc-responsive skin disease in dogs: a dying dermatosis? JSAP 30 (4), 213-5 VetMedResource.
  • van den Broek A H M & Thoday K L (1986) Skin disease in dogs associated with zinc deficiency: a report of five cases. JSAP 27 (5), 313-323 VetMedResource.

Other sources of information

  • Willemse T (1992)Zinc-related Cutaneous Disorders.In:Current Veterinary TherapyXI, R W Kirk (ed). Philadelphia: W B Saunders.
  • Lewis L D (1981)Cutaneous manifestations of nutritional imbalances.Proceedings of the 48th Annual Meeting of the American Animal Hospital Association. pp 263.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!