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Skin: vesicular cutaneous lupus erythematosus

icanis

Synonym(s): VCLE, ulcerative dermatosis of the Shetland sheepdog and (rough) collie, UDSSC


Introduction

  • Cause: idiopathic, autoimmune.
  • Signs: axillary and inguinal ulcers with serpiginous, annular or polycyclic borders.
  • Primarily, but not exclusively Shetland sheepdogs and rough collies.
  • Diagnosis: breed, clinical signs, histopathology.
  • Treatment: immunosuppressive and immunomodulating ± antimicrobial.
  • Prognosis: variable response to therapy and incurable.
  • Human equivalent: vesicular variant of subacute cutaneous lupus erythematosus (SCLE).

Pathogenesis

Pathophysiology

  • UV damage causing relocation of nuclear antigens into the cytoplasm and cell membrane.
  • Antibodies against extractable nuclear antigens demonstrable in 82% cases by immunoblotting.
  • Antibodies against Ro/SSA and/or La/SSB in sera in 55% cases by ELISA (cf. SCLE in man).

Timecourse

  • Persistent, may wax and wane.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Olivry T, Linder K E, Banovic F (2018) Cutaneous lupus erythematosus in dogs: a comprehensive review. BMC Vet Res 14 (1), 132 PubMed.
  • Lehner G M & Linek M (2013) A case of vesicular cutaneous lupus erythematosus on a Border Collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. Vet Dermatol 24, 639-e160 PubMed.
  • Gibson I and Barnes J (2011) Vesicular Cutaneous Lupus Erythematosus in a Border Collie in New Zealand. N Z Vet J 59, 153 SciQuest.
  • Font A et al (2006) Treatment with oral ciclosporin A of a case of vesicular cutaneous lupus erythematosus in a rough collie. Vet Dermatol 17, 440-442 PubMed.
  • Jackson H A et al (2004) Immunopathology of vesicular cutaneous lupus erythematosus in the rough collie and Shetland sheepdog: a canine homologue of subacute cutaneous lupus erythematosus in humans. Vet Dermatol 15, 230-239 PubMed
  • Jackson H A (2004) Eleven cases of vesicular cutaneous lupus erythematosus in Shetland Sheepdogs and rough collies: clinical management and prognosis. Vet Dermatol 15, 37-41 PubMed.

Other sources of information

  • Autoimmune and Immune-mediated Diseases. In: Miller W H, Griffin C E & Campbell K L: Muller and Kirk’s Small Animal Dermatology. 7th edn. W B Saunders, Philadelphia (2013), pp 460-461.
  • Ulcerative Dermatoses. In: Nuttall T, Harvey R G, McKeever P J (eds): Skin Disease of the Dog and Cat. 2nd Ed. Manson Publishing, London, UK (2011), pp113-114.
  • Riviere C (1999) Autoimmune dermatoses. In: Guagere E & Prelaud P (eds): A Practical Guide to Feline Dermatology. Merial pp 280-281.

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