ISSN 2398-2969      

Skin: panniculitis

icanis

Synonym(s): Nodular panniculitis, necrotising steatitis


Introduction

  • Cause: inflammation of subcutaneous fat.
  • Signs: sinus tracts, nodules and fistulae.
  • Diagnosis: history, signs, histopathology.
  • Treatment: surgery, antibiosis, immunosuppressive glucocorticoids, vitamin E.
  • Prognosis: varies according to cause.

Pathogenesis

Etiology

Predisposing factors

General
  • May develop after subcutaneous injection.
  • May develop <7 days following surgery.

Pathophysiology

  • Inflammation of subcutaneous fat.
  • Damage to fat cells releases lipid into extracellular space.
  • Lipid is converted to fatty acids and these are potent inducers of inflammation.
  • Granulomatous reactions to fatty acids develop.
  • Can be sterile or associated with infection.

Timecourse

  • Weeks.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lemarie S L (1999) Mycobacterial dermatitis. Vet Clin North Am Small Anim Pract 29 (6), 1291-1301 PubMed.
  • Torres S M (1999) Sterile nodular dermatitis in dogs. Vet Clin North Am Small Anim Pract 29 (6), 1311-1323 PubMed.
  • DeManuelle T C & Stannard A A (1998) Difficult dermatological diagnosis. Sterile nodular panniculitis. JAVMA 213 (3), 356-357 PubMed.
  • Paterson S (1995) Sterile idiopathic pedal panniculitis in the German shepherd dog - clinical presentation and response to treatment of four cases. JSAP 36 (11), 498-501 PubMed.
  • Brown P J, Mason K V, Merrett D J, Mirchandani S & Miller R I (1994) multifocal necrotizing steatitis associated with pancreatic carcinoma in three dogs. JSAP 35 (3), 129-133 Wiley Online Library.
  • Scott D W & Anderson W I (1988) Panniculitis in dogs and cats - a retrospective study of 78 cases. JAAHA 24 (5), 551-9 VetMedResource.
  • Moreau P M, Fiske R A, Lees G E & Corrier D E (1982) Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog. JAVMA 180 (4), 422-425 PubMed.

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