Canis ISSN: 2398-2942
Skin: keratinization disorders
Synonym(s): Seborrhea; Disorders of cornification
Contributor(s): Rosanna Marsella, David Scarff, David Godfrey
- Disorders of keratinization or cornification alter the surface appearance of the skin by affecting the structure and function of the epidermis. Proliferation, differentiation and desquamation of the stratum corneum or epidermal lipid formation are abnormal. Hyperkeratosis with parakeratotic or orthokeratotic changes is usual and shows as skin that is visibly thickened as well as being thickened on histopathology. Occasionally hypokeratosis is present - usually visible only on histopathology.
- Keratinization defects also affect transepidermal water loss rates.
- Cause: congenital or acquired.
- Signs: may be localized or generalized.
- Secondary keratinization disorders:
- Any dermatosis can have elements of keratinization disease.
- Generalized primary conditions:
- Localized primary conditions:
- Secondary complications:
- Malassezia spp Skin: malassezia disease (less often Candida spp Candida albicans). Yeasts grow well in inflamed and oily skin. Their presence induces keratinocyte proliferation and so there is a vicious circle.
- Recent references from PubMed and VetMedResource.
- Campbell K L (1994) Seborrheic skin disorders and their treatment in dogs. Clinical Dermatology 12 (4), 551-558 PubMed.
- Shanley K J (1990) The seborrheic disease complex. An approach to underlying causes and therapies. Vet Clin North Am Small Anim Pract 20 (6), 1557-1577 PubMed.
Other sources of information
- Miller W H, Griffin C E & Campbell K L (2013) Topical formulation. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 117.
- Miller W H, Griffin C E & Campbell K L (2013) Synthetic retinoids. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 139.
- Miller W H, Griffin C E & Campbell K L (2013) Keratinization defects. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 630.