Canis ISSN: 2398-2942

Skin: epidermolysis bullosa

Contributor(s): David Scarff, Susan E Shaw

Introduction

  • Cause: rare hereditary mechano-bullous disorder.
  • Signs: blisters, vesicles and erosions in skin and mucous membranes in response to trauma.
  • Diagnosis: clinical signs, age of onset, histopathology.
  • Treatment: minimize trauma, treat secondary infections, euthanasia.
  • Prognosis: poor.

Pathogenesis

Etiology

  • Inherited defect.
  • May be autosomal recessive pattern, mode varies.

Pathophysiology

  • Inherited defect leading to loss of skin/dermis adhesion.
  • Fragility of dermo-epidermal junction.
  • Believed due to faulty keratin production/anchoring fibril defects.
  • Subcategories lead to vesicles originating at various level.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

Other sources of information

  • Koch H & Walder E (1993)Epidermolysis bullosa dystrophia in Beaucerons.In: von Tscharner, C and Halliwell, R E W (eds)Advances in Veterinary Dermatology.Vol 1, pp 441. Oxford: Bailliere Tindall.


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