Canis ISSN: 2398-2942

Skin: color dilution alopecia

Synonym(s): Color mutant alopecia, Blue dog disease

Contributor(s): Rosanna Marsella, David Scarff

Introduction

  • Uncommon hereditary disease of some blue or fawn colored dogs.
  • Cause: genetic.
  • Signs: poor coat, alopecia +/- folliculitis - usually spares solid color areas such as tan points.
  • Diagnosis: breed, coat color, clinical signs, histopathology.
  • Treatment: grooming, shampoos, antibiotics.
  • Prognosis: good although lifelong condition.

Pathogenesis

Pathophysiology

  • Poorly understood influence of coat color genes.
  • Dilute colored hairs have large or very large melanosomes (macromelanosomes Color-dilution alopecia showing macromelanosomes in hair shaft 01 ), leading to brittleness and fracture of hair shaft.
  • May be degenerative processes in hair bulb melanocytes.

Timecourse

  • Lifelong.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cerundolo R (1999) Symmetrical alopecia in the dog. In Practice 21 (7), 350-359 VetMedResource.
  • Beco L et al (1996) Color dilution alopecia in seven dachshunds - a clinical study and the hereditary, microscopical and ultrastructural aspects of the disease. Vet Dermatol 7 (2), 91-7 VetMedResource.
  • Miller W H (1990) Color dilution alopecia in Doberman Pinschers with blue or fawn coat colors - a study on the incidence and histopathology of this disorder. Vet Dermatol (3), 113-22 VetMedResource.

Other sources of information

  • Scott D W, Miller W H & Griffin C E (1995)Small Animal Dermatology. 5th edition. Philadelphia: W B Saunders. ISBN 0 7216 4850 9.
  • Yager J A & Wilcock B P (1994)Color Atlas and Text of Surgical Pathology of the Dog and Cat.London: Wolfe Publishing, Mosby Year Book Europe. ISBN 0 7234 1827 6.
  • Gross T L, Irkhe P J & Walder E J (1992)Veterinary Dermatopathology. St Louis: Mosby Year Book. ISBN 0 8016 5809 8.


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