ISSN 2398-2969      

Pure red cell aplasia

icanis
Contributor(s):

Prof Bernard Feldman


Introduction

  • Selective failure of erythropoiesis (maturation arrest at early normoblast stage) but normal production of white blood cells and platelets.
  • Insidious onset, non-regenerative anemia.
  • Cause: potentially immune-mediated.
  • Signs: weight loss.
  • Diagnosis: bone marrow aspirate.
  • Treatment: immunosuppressive therapy may, on occasion, be helpful.
  • Prognosis: good to fair.

Pathogenesis

Etiology

  • Idiopathic.
  • Immune-mediated is possible.
  • May be secondary to parvovirus infection - suggested but not proven.

Pathophysiology

  • Serum immunoglobulin G inhibitor → decreased erythroid colony precursors → insidious onset anemia → physiological compensation → relatively mild signs even if severe anemia.

Timecourse

  • Gradual onset over weeks or months.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!