Canis ISSN: 2398-2942

Polyarthritis / meningitis syndrome

Synonym(s): Steroid-responsive meningitis-arteritis;SRMA

Contributor(s): Laurent Garosi, John Innes

Introduction

  • May overlap with polyarteritis nodosa Polyarteritis nodosa and polyarthritis of Japanese Akita.
  • Steroid responsive meningitis arteritis (SRMA Steroid-responsive meningitis-arteritis (SRMA) ) is currently the most widely accepted term.
  • Cause: immune-mediated disease.
  • Signs: stiffness, depression.
  • Diagnosis: hematology, serology, CSF analysis.
  • Treatment: immunosuppressive therapy.
  • Prognosis: fair.

Pathogenesis

Pathophysiology

  • Thought to be immunological mechanism due to response to glucocorticoid therapy.
  • Pedigree analysis of affected Akitas suggests that the disease is inherited.
  • Activated T cells, implying exposure to a previous or existing antigen, have sometimes been found. This suggests that dogs with this condition may have been exposed to an exogenous infectious or non-infectious agent or to an endogenous antigen.
  • Affected dogs tend to produce high concentrations of intrathecal IgA and high serum IgA. These findings suggest that IgA plays an important role in the pathogenesis.

Timecourse

  • Usually fairly acute onset (days to weeks).
  • Disease usually cyclic with periods of remission.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johnson K C & Mackin A (2012) Canine immune-mediated polyarthritis. JAAHA 48 (1), 12-17 PubMed.
  • Tipold A & Schatzberg S J (2010) An update on steroid responsive meningitis-arteritis. JSAP 51 (3), 150-154 PubMed.
  • Lowrie M, Penderis J et al (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Vet J 182 (1), 125-130 PubMed.
  • Webb A A, Taylor S M, Muir G D (2002) Steroid-responsive meningitis-arteritis in dogs with non-infectious, nonerosive, idiopathic, immun-mediated polyarthritis. JVIM 16 (3), 269-273 PubMed.
  • Cizinauskas S, Jaggy A & Tipoid A (2000) Long-term treatment of dogs with steroid-responsive meningitis-arteritis - clinical, laboratory and therapeutic results. JSAP 41 (7), 295-301 PubMed.
  • Dougherty S A, Center S A, Shaw E E & Erb H A (1991) Juvenile-onset polyarthritis syndrome in Akitas. JAVMA 198 (5), 849-856 PubMed.
  • Meric S M (1988) Canine meningitis a changing emphasis. JVIM 2 (1), 26-35 PubMed.


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