Canis ISSN: 2398-2942

Pancreas: neoplasia of the exocrine pancreas (adenocarcinoma)

Contributor(s): Andrew Gardiner, Laura Garrett, James Simpson

Introduction

  • Cause: rare as primary (<0.5% of all cancers) neoplasia of acinar or duct cells in central portion of pancreas. Usually occur in older animals, specifically Airdale terriers Airedale Terrier.
  • Signs: non-specific - vomiting, fever, weakness, variable abdominal pain.
  • Diagnosis: radiography, ultrasound, laparotomy and tissue biopsy.
  • Treatment: symptomatic, not curative.
  • Prognosis: very poor - often locally invasive and metastasized at presentation. If diagnosed at exploratory laparotomy; intra-operative euthanasia should be considered.

Pathogenesis

Etiology

  • Adenocarcinoma of pancreatic duct or acinar cells.

Pathophysiology

  • Malignant tumor arising from cells of ducts or acinae → pancreatic enlargement ( → abdominal mass +/- pain, intestinal obstruction); abnormal function ( → maldigestion, anorexia, weight loss); biliary obstruction ( → jaundice).
  • Metastasis → bone ( → pathological fractures) and/or soft tissues.
  • Some tumors → increased gastrin secretion → inappropriate acid secretion by stomach → gastroduodenitis.

Timecourse

  • Rapid metastasis - usually already occurred at time of presentation.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lamb C R, Simpson K W, Boswood A & Mathewman L A (1995) Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec 137 (3), 65-68 PubMed.
  • Anderson N V & Johnson K K (1967) Pancreatic carcinoma in the dog. JAVMA 150 (3), 286-95 PubMed.

Other sources of information

  • Williams D A (1996)The Pancreas. In:Strombeck's Small Animal Gastroenterology.W Guildfordet al(eds), Saunders W B, Philadelphia, pp 381-411.
  • Bunch S E (1992)diseases of the exocrine pancreas.In:Handbook of Small Animal Practice.Ed: R V Morgan. 2nd edn. Churchill: Livingstone, NY, USA.
  • Withrow S J (1989) Tumours of the gastrointestinal system: exocrine pancreas.In:Clinical Veterinary Oncology. Eds S J Withrow and E G MacEwen. Lippincott, Philadelphia. p 192.


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