Canis ISSN: 2398-2942

Liver: copper accumulation - West Highland White and Skye Terriers

Contributor(s): Kyle Braund

Introduction

  • Signs: may be clinically normal but have abnormal copper accumulations in the liver.
  • Diagnosis: hepatic biopsy if any hepatic disease of ill-defined cause.
  • Treatment: same as for Copper toxicosis Copper toxicosis (Bedlington Terrier) (Bedlington Terrier).
  • Same as: Acute hepatic disease Liver: acute disease.

Pathogenesis

Etiology

Pathophysiology

  • Poorly understood but in some dogs appears to be associated with copper accumulation in the liver → acute hepatitis, chronic hepatitis and cirrhosis.
  • In Skye Terriers, hepatitis is speculated to be a disorder of disturbed bile secretion with subsequent accumulation of copper.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Thornburg L P et al (1996) The relationship between hepatic copper content and morphologic changes in the liver of West Highland White Terriers. Vet Pathol 33 (6), 656-661 PubMed.
  • Hayward S et al (1988) Hepatitis and copper accumulation in Skye Terriers. Vet Pathol 25 (6), 408-414 PubMed.

Other sources of information

  • Johnson S E (2000)Chronic hepatic disorders.In:Textbook of Veterinary Internal Medicine.5th edn. Eds: S J Ettinger & E C Feldman. Philadelphia: W B Saunders. pp 1298-1325.


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