Canis ISSN: 2398-2942

Immunology: transient hypogammaglobulinemia of infancy

Contributor(s): Ansar Ahmed, Michael Day, Richard Squires

Introduction

  • Self-limiting immunoglobulin deficiency,uncommon in dogs.
  • Cause: failure to synthesize own immunoglobulins until much later than normal neonatally.
  • Signs: seen at 2-3 months of age as passively acquired antibody levels fall.
  • Primarily complaints of bacterial respiratory tract infections and dermatitis.
  • Diagnosis: signs, measurement of serum immunoglobulin.
  • Treatment: symptomatic treatment of infections.
  • Prognosis: normal amounts of immunoglobulins synthesized by 5-6 months of age accompanied by disappearance of clinical signs.

Pathogenesis

Pathophysiology

  • In the young puppy, an abnormally prolonged delay in the onset of immunoglobulin synthesis.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

Other sources of information

  • Felsberg P J (1992)Primary immunodeficiencies.In:Current Veterinary Therapy XI: Small Animal Practice.Eds: Kirk R W & Bonagura J D. Philadelphia: W B Saunders. pp 448-453.


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