ISSN 2398-2969      

Idiopathic generalized tremor syndrome

icanis

Synonym(s): Shaker dog disease, Idiopathic cerebellitis, Sporadic acquired tremors of adult dogs, White dog shaker disease


Introduction

  • Cause: possibly an immune-mediated reaction to tyrosine-producing cells which are important in neurotransmitter production.
  • Occurs most often in small white breeds.
  • Signs: tremors in all four limbs and the head which may worsen with exercise, stress or excitement but may disappear with sleep.
  • Diagnosis: signs and breed.
  • Treatment: immunosuppressive doses of glucocorticoid.
  • Prognosis: good although signs will not resolve in some cases.

Pathogenesis

Etiology

  • Inflammatory brain disease.
  • No obvious etiology has been found as a cause of the encephalitis Encephalitis.

Specific

  • Traditionally white dogs (but now it is accepted any color of dog can be affected.

Pathophysiology

  • The disease is often associated with a mild encephalitis.
  • Very mild diffuse non-suppurative encephalomyelitis → immune attack on tyrosine-producing cells → decreased production of neurotransmitters → tremor.

Timecourse

  • Generally a chronic disease.
  • Tumors can occur acutely.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ives E, Mackillop E, Olby N J (2018) Saccadic oscillations in 4 dogs and 1 cat. JVIM 32, 1392-1396 PubMed
  • Bagley R S, Kornegay, Wheeler S J & Cauzinille L (1993) Generalized tremors in Maltese - clinical findings in seven cases. JAAHA 29 (2), 141-145 VetMedResource.
  • Bagley R S (1992) Tremor syndromes in dogs - diagnosis and treatment. JSAP 33 (10), 485-90 VetMedResource.

Other sources of information

  • Lowrie M and Garosi L (2016) Classification of involuntary movements in dogs: Tremors and Twitches. Vet J 214, 109-116 PubMed
  • Farrow B R H (1986) Generalized tremor syndrome. In: Current Veterinary Therapy IX.W B Saunders. pp 800-801.

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