Canis ISSN: 2398-2942

Hypertrophic osteopathy

Synonym(s): Hypertrophic pulmonary ostropathy, HO, bone neoplasia lameness cancer tumor

Contributor(s): Prof Walter Renberg

Introduction

  • A secondary change indicating another disease process, eg lung tumors, other thoracic conditions, esophageal tumor, adenocarcinoma of liver/prostate, embryonal rhabdomyosarcoma of bladder.
  • Cause: increased peripheral blood flow and deposition of new periosteal bone along long bone diaphyses (especially extremities).
  • Signs: enlargement of distal extremities, sore limbs, lameness.
  • Diagnosis: signs, radiography.
  • Treatment: treatment of underlying causal condition +/- analgesia.
  • Prognosis: dependent on successful treatment of primary disease process.

Pathogenesis

Etiology

  • Unknown, but thought to be of neural origin.

Specific

  • Pre-existence of other specific primary disease:
    • Primary or metastatic thoracic neoplasia Lung: pulmonary neoplasia.
    • Other non-neoplastic thoracic condition (heartworm infestation, fungal etc).
    • Embryonal rhabdomyosarcoma.
    • Liver adenocarcinoma Adenoma / adenocarcinoma.
    • Other abdominal conditions.

Pathophysiology

  • Proliferation of new metaphyseal periosteal bone - secondary to another disease process.
  • Various theories.
  • Irritation of vagus or intercostal nerves causes a change in peripheral blood flow → congestion of peripheral tissue → periosteal response.

Timecourse

  • Lameness develops over several weeks.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Kell M J (1984) Longterm survival of a case of hypertrophic osteopathy with regression of bony lesions. J Am Anim Hosp Assoc 20, 439.
  • Susaneck S J & Macy D W (1982) Hypertrophic osteopathy. Comp Cont Educ 4 (8), 689-94 VetMedResource.


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