Canis ISSN: 2398-2942

Fibrosarcoma

Synonym(s): FSA

Contributor(s): Ruthanne Chun, Isabelle Desmas-Bazelle

Introduction

  • Malignant, locally invasive tumor of mesenchymal cells.
  • Sites: axial skeleton and flat bone (pelvis and scapular), subcutaneous tissues anywhere on body, mouth, nasal cavity.
  • Signs: firm, subcutaneous mass; may involve underlying skeletal muscle or bone.
  • Metastasis - uncommon.
  • Diagnosis: histopathology, radiography/CT scan, cytology.
  • Treatment: amputation/wide surgical resection, aiming for 3-5 cm margins around tumor and on fascial plane deep to gross tumor (difficult - invasive).
  • Prognosis: recurrence rate high following incomplete resection - better following amputation.

Pathogenesis

Etiology

  • Unknown.
  • Radiation, trauma, foreign bodies, orthopedic implants, and the parasite Spirocerca lupi Canine spirocercosis have been associated with sarcomas.

Pathophysiology

  • Variants:
    • Malignant fibrous histiocytoma: neoplasia of mesenchymal cells arising in same potential sites as FSA.
    • Also occurs as a giant, multinucleated cell variant.
  • Locally invasive tumor may → extension to surrounding tissues/bone → bone destruction/proliferation.
  • Metastasis - uncommon (depend on the grade).

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Frazier S A, Johns S M, Ortega J, Zwingenberger A L, Kent M S, Hammond G M, Rodriguez C O Jr, Steffey M A, Skorupski K A (2012) Outcome in dogs with surgically resected oral fibrosarcoma (1997-2008). Vet Comp Oncol 10 (1), 33-43 PubMed.
  • Dennis M M, McSporran K D, Bacon N J, Schulman F Y, Foster R A, Powers B E (2011) Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs. Vet Pathol 48 (1), 73-84 PubMed.
  • McChesney S L, Withrow S J et al (1989) Radiotherapy of soft tissue sarcomas in dogs. JAVMA 194 (1), 60-63 PubMed.
  • Weinstein M J, Carpenter J L et al (1989) Nonangiogenic and nonlymphomatous sarcomas of the canine spleen - 57 cases (1975-1987). JAVMA 195 (6), 784-788 PubMed.

Other sources of information

  • Withrow S J, Vail D M, Page R L (2013)Small Animal Clinical Oncology.5th edn. Elsevier.


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