Canis ISSN: 2398-2942

Eye: persistent hyperplastic primary vitreous

Synonym(s): PHPV, Persistent hyperplastic tunica vasculosa lentis (PHTVL), PHTVL/PHPV

Contributor(s): Natasha Mitchell, David Gould

Introduction

  • Cause: developmental ocular disorder.
  • Signs: there is a spectrum of effects, from no visible outward signs to intraocular hemorrhage, cataracts and blindness.
  • Diagnosis: ophthalmoscopy, ocular ultrasonography.
  • Treatment: none unless vision impairment is caused by cataracts, which can be surgically removed by modified phacoemulsification.
  • Prognosis: more severely affected dogs have poor vision. Phacoemulsification is more complicated in these cases and so the risks are greater.

Pathogenesis

Pathophysiology

  • As a result of the anomalous development of the primary vitreous, it persists during formation of the secondary vitreous, when it would normally regress.
  • It is associated with hyperplasia of the mesodermal elements contained in the primary vitreous and hyaloid artery system, combined with subsequent incomplete regression.
  • In the Dobermann, the inheritance pattern is thought to be incomplete dominance.
  • Similarly, genetic studies in the Staffordshire Bull Terrier suggest that PHPV is either caused by a single mutation with a dominant or co-dominant mode of inheritance, or is a more complex condition with perhaps several genes involved. Further studies are on-going at the Animal Health Trust, UK.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Gemensky-Metzler A J, Wilkie D A (2004) Surgical management and histologic and immunohistochemical features of a cataract and retrolental plaque secondary to persistent hyperplastic tunica vasculosa lentis/persistent hyperplastic primary vitreous (PHTVL/PHPV) in a Bloodhound puppy. Vet Ophthalmol 7, 369-375 PubMed.
  • Pollard Z F (1997) Persistent hyperplastic primary vitreous: diagnosis, treatment and results. Transactions of the American Ophthalmological Society 95, 487-549 PubMed.
  • Leon A, Curtis R, Barnett K C (1986) Hereditary persistent hyperplastic primary vitreous in the Staffordshire bull terrier. JAAHA 22 (6), 765-774 VetMedResource.
  • Stades F C (1983) Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in doberman pinschers. Genetic aspects. JAAHA 19 (6), 957-964 VetMedResource.
  • Stades F C (1980) Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous (PHTVL/PHPV) in 90 closely related Doberman Pinschers: clinical aspects. JAAHA 16 (5), 739-751 VetMedResource.
  • Reese A B (1955) Persistent hyperplastic primary vitreous. American Journal of Ophthalmology 40 (3), 317-331 PubMed.

Other sources of information

  • Veterinary Ophthalmology (2013) 5th edn. Edited by Gelatt K N, Gilger B C & Kern T J. John Wiley and Sons, Ames, Iowa. ISBN 978-0-470-96040-0

Organisation(s)


ADDED