ISSN 2398-2969      

Enteritis: eosinophilic

icanis
Contributor(s):

James Simpson


Introduction

  • A form of inflammatory bowel disease (IBD).
  • Cause: eosinophilic infiltration of any region of intestinal mucosa, possibly caused by endoparasitic or dietary hypersensitivity.
  • Signs: chronic diarrhea of small or large bowel origin, chronic vomiting, weight loss.
  • Diagnosis: intestinal histopathology and circulating eosinophils.
  • Treatment: eliminate endoparasites and dietary manipulation; oral prednisolone or azathioprine often required.

Pathogenesis

Etiology

  • Possible allergic reaction to dietary allergens.
  • Endoparasitism: toxocara, hookworms, whipworms, giardiasis.
  • Immune dysregulation.

Specific

  • Heavy worm burden.

Pathophysiology

  • Immune response to luminal, mucosal antigen.
  • Loss of immune tolerance to dietary protein.
  • May be associated with increased intestinal permeability.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johnson S E (1992) Canine eosinophilic gastroenterocolitis. Semin Vet Med Surg (Small Anim) 7 (2), 145-152 PubMed.
  • Quigley P J & Henry K (1981) Eosinophilic enteritis in the dog: a case report with a brief review of the literature.​ J Comp Pathol 91 (3), 382-387 PubMed.
  • Hayden D W & Van Kruiningen H J (1973) Eosinophilic gastroenteritis in German Shepherd dogs and its relationship to visceral larva migrans. JAVMA 162 (5), 379-384 PubMed.

 

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