Canis ISSN: 2398-2942

Diarrhea: chronic - due to prolonged antibiosis

Introduction

  • Cause: altered small intestinal microbial balance with 'foreign' bacteria proliferating.
  • Signs: clinically well, chronic diarrhea - usually self-limiting.
  • Diagnosis: signs and history of recent antibiotic therapy.
  • Treatment: probiotics to aid re-establishment of normal flora.
  • Prognosis: usually good.

Pathogenesis

Etiology

  • Normal small intestinal bacterial population very stable with relatively high numbers ofLactobacillispp and relatively low numbers ofE. coli Escherichia coli. Antibiotics may reverse this balance with subsequent mucosal damage byE. coliandClostridia Clostridium perfringens.

Predisposing factors

General
  • Stress.

Pathophysiology

  • Proliferation of 'foreign' bacteria in the small intestine → mucosal invasion by bacteria → mucosal damage.

Timecourse

  • May be after only a few days of antibiotic treatment.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers


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