ISSN 2398-2969      

Cleft lip and palate

icanis
Contributor(s):

MarkThompson


Introduction

  • Defect in fusion of secondary palate seen at birth - may be associated with harelip.
  • Cause: stress and genetic factors.
  • Signs: rhinitis +/- pneumonia.
  • Treatment: surgical closure.
  • Prognosis: reasonable, variable surgical success rates, fatal if not able to suckle.

Pathogenesis

Etiology

  • Multiple genetic factors, stress, teratogens.

Pathophysiology

  • Failure of secondary palate to fuse during development → communication between oral and nasal cavities → failure to suckle due to inability to develop negative pressure required → also passage of food to nasal cavity → rhinitis and possible aspiration pneumonia.

Timecourse

  • Days/weeks.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

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