Canis ISSN: 2398-2942

Chondrosarcoma

Synonym(s): CSA

Contributor(s): Prof Walter Renberg

Introduction

  • Account for <10% of primary bone tumors.
  • Most commonly affect axial skeleton, ie flat bones.
  • Arise from cartilage - malignant, metastasizing primarily to lung.
  • Incidence: mostly axial skeleton of large (not giant) breeds.
  • Signs: lameness, swelling +/- pain.
  • Diagnosis: radiography, histopathology.
  • Treatment: limb amputation/bone resection.
  • Prognosis: good for low-grade tumors following early treatment; poor for high-grade tumors of long bones (slower growing and lower metastatic rate than osteosarcoma Osteosarcoma ).

Pathogenesis

Etiology

  • Unknown.

Pathophysiology

  • Malignant tumor arising from cartilage.
  • Variable histological grade and malignancy.
  • Proliferation of malignant cartilage cells → swelling around tumor site → clinical signs dependent on location.
  • Metastasize to any tissue, especially lungs.
  • Rib involvement may → intrathoracic extension → pleural effusion Pleural: effusion.

Timecourse

  • With high-grade malignancy, metastasis may occur within weeks.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Davidson J R (1995) Canine and feline chondrosarcoma. Comp Cont Educ 17 (9), 1109-1114 VetMedResource.
  • Pupovitch C A, Weinstein M J, Goldschmidt M H & Shafer P S (1994) Chondrosarcoma - a retrospective study of 97 dogs (1987-1990). JAAHA 30 (1), 81-85 VetMedResource.


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