ISSN 2398-2969      

Brush border membrane disease

icanis

Introduction

  • Cause: primary deficiencies of brush border enzymes, eg lactase, sucrase - mainly theoretical in dogs.
  • Secondary deficiencies of disaccharidase, brush border peptidase due to bacterial overgrowth or small intestinal diseases, eg eosinophilic enteritis, lymphocytic enteritis.
  • Signs: chronic diarrhea.
  • Prognosis: good with treatment.

Pathogenesis

Etiology

  • Small intestinal diseases.
  • Deficiency of specific brush border enzymes.

Predisposing factors

General

Pathophysiology

  • Small intestinal mucosal damage→ reduction in activity of disaccharidase/brush border peptidase → malabsorption of disaccharides/oligopeptides.
  • Specific deficiency of brush border enzyme, ie lactase, sucrase, enterokinase, other peptidases → malabsorption of lactose/sucrose and protein.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pemberton P W et al (1997) An aminopeptidase N deficiency in dog small intestine. Res Vet Sci 63 (2), 133-8 PubMed.
  • Fyfe J C et al (1991) Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption. J Biol Chem 266 (7), 4489-4494 PubMed.
  • Batt R M (1990) Relationship between diet and malabsorption in dogs. JSAP 31 (10), 489-493 VetMedResource.
  • Batt R M (1989) Chronic enteropathies in the dog. JSAP 30 (1), 3-12 VetMedResource.

Other sources of information

  • Harris J Tet al(1985)Congenital and inherited defects of enterocytes.In:Disorders of the Small Intestine.Booth C C, Neale G (editors), Blackwells, Oxford. p52.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code