Bovis ISSN 2398-2993

Propylene glycol

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Propylene glycol.

Class of drug

  • Glucose precursor in ruminants.
  • Humectant.
  • Vehicle.
  • Solvent.

Description

Chemical name

  • 1,2-propanediol.
  • 1,2-dihydroxypropane.

Molecular formula

  • C3H8O2.

Molecular weight

  • 76.10.

Physical properties

  • Hygroscopic, viscous liquid.
  • Slightly acrid taste.
  • Melting point: -59°C.
  • Miscible with water, acetone and chloroform.

Storage requirements

  • <25°C.
  • Protect from frost.
  • Protect from light.

Uses

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Indications

  • Ketosis in cattle.
  • Propylene glycol is also a constituent in some skin creams. 

Administration

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Precautions

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Interactions

With other drugs

  • Glucocorticoid and IV Glucose solution often administered at same time as propylene glycol in the treatment of ketosis.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.

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